Testicular cancer in heterosexual men

Ho Chi Minh City 40-year-old patient, female body but testicle in left inguinal canal, recently groin area gradually enlarged and painful, cancer detected.

At the age of three, the patient was found to have a left testicle in the inguinal canal (cryptorchitis), the hospital sent him home and did not intervene because it did not cause any inconvenience. Earlier this year, the patient noticed that the left groin area began to grow larger and became more painful, so he went to a local hospital for examination, then was transferred to Cho Ray Hospital.

On May 30, Dr. Tran Trong Tri, Department of Urology, said that the examination results showed that the patient's chest was underdeveloped; the clitoris was enlarged, with labia majora on both sides; no menstruation, and the size of the tumor in the left groin area was about 5x8 cm.

DNA testing showed that the patient was an intersex person with a mosaic chromosome set of 46, XX/46, XY. Mosaic intersex is a disorder of sex differentiation, with male and female genitalia in the same individual, with an incidence of 1/100,000 live births.

Assessing this as an extremely rare case, the multidisciplinary team consulted and decided to perform surgery to remove the left testicular tumor. During the surgery, the doctor discovered that the patient still had a right ovary and no uterus. The pathological result was a testicular tumor (seminoma - germ cell cancer in the testicles, commonly found in young men).

The patient then received 6 cycles of adjuvant chemotherapy with good response.

Doctor Tri is examining a patient. Photo: Provided by the hospital — Doctor Tri is examining a patient. Photo: *Provided by the hospital*

Doctor Vuong Dinh Thy Hao, Head of the Chemotherapy Department, added that testicular cancer is very common in people with gender dysphoria who have two reproductive organs on one body. The patient was hospitalized late, but fortunately was diagnosed, had surgery and received successful chemotherapy.

Doctor Thy Hao recommends that patients and their families, if unfortunately in this situation, should go to a medical facility with a Urology department for examination, assessment and timely treatment to avoid possible serious consequences. In particular, the risk of cancer is very high in cases of hidden testicles in the abdomen.

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