Blood test of 100-year-old finds key to longevity

Swedish research shows that the blood of people over 100 years old has lower levels of glucose, creatinine and uric acid after the age of 60.

The study, conducted by the Karolinska Institute and published in the journal GeroScience on October 10, is the largest study to measure and track the levels of different molecules in people born between 1893 and 1920. According to experts, a simple blood test can predict a person's chances of living to 100 years old.

Scientists evaluated data on blood molecules from more than 44,500 Swedes who were enrolled in clinical trials between 1985 and 1996 and followed up until 2020. They focused specifically on the group born between 1893 and 1920. They then compared the data from this group with younger people.

The analysis identified 12 molecules in the blood that are linked to metabolism, inflammation, liver and kidney function, aging, or death. Total cholesterol and glucose are markers of metabolism, uric acid indicates inflammation, enzymes indicate liver health, and creatinine is a measure of kidney health. Experts say that, except for liver enzymes and albumin, all other molecules are linked to a person's ability to live to 100.

An elderly woman celebrates her 100th birthday at a nursing home. Photo: Stokesentinel

In volunteers with high levels of total cholesterol and iron, and low levels of glucose, creatinine, uric acid, and liver enzymes, survival to 100 years was higher.

"Overall, we found that people who lived to their 100th birthday had lower glucose, creatinine and uric acid levels from their 60s onwards. Very few people over 100 had blood glucose levels above 6.5 or creatinine levels above 125 when they were alive."

The researchers said the findings suggest a “potential link” between metabolism, nutrition and longevity. However, the study did not suggest a lifestyle factor or gene responsible for blood levels of the molecules.

Thuc Linh (According to Independent )

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