After a month of dry cough with increasing severity, the male patient went to the doctor and was found to have large cell neuroendocrine carcinoma combined with squamous cell carcinoma.
According to the patient, for the past month, male patient CTH (76 years old, Bac Ninh) has had symptoms of dry cough, which has lasted for a month and is gradually increasing in severity. Mr. H. has used medicine but it has not improved, so he decided to go to Medlatec General Hospital for examination.
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After clinical examination, the doctor prescribed the necessary paraclinical techniques for diagnosis. The chest CT scan revealed a dense opaque mass in the upper lobe of the left lung, measuring 43x45mm, with uneven contrast.
Detecting abnormal signs, the doctor ordered a histopathological test, diagnosing non-small cell carcinoma. After performing an immunohistochemical test to confirm the diagnosis, the patient's condition was concluded to be large cell neuroendocrine carcinoma combined with poorly differentiated squamous cell carcinoma (stage T2bNxMx). After being accurately diagnosed, the patient was advised by the doctor on the appropriate treatment direction.
It is known that large cell neuroendocrine cancer (belonging to the neuroendocrine cancer group) is a poorly differentiated carcinoma, consisting of large cells with neuroendocrine features, prominent nuclei, high mitosis, and necrosis.
This disease belongs to the group of neuroendocrine tumors according to the WHO 2021 classification, chest tumors, rare, accounting for only 3% of lung cancers.
Large cell neuroendocrine carcinoma has a very high malignancy rate, high recurrence rate, and lower survival rate than other non-small cell cancers.
Even when detected early, the average survival time after detection
In Mr. H's case, it is even rarer when large cell neuroendocrine carcinoma is accompanied by squamous cell carcinoma (a subtype of large cell neuroendocrine carcinoma).
According to Dr. Vu Xuan Ngoc, Medlatec Pathology Center, this is probably the first case discovered in Vietnam, because diagnosing this case is very difficult.
Doctors at Medlatec Hospital said that large cell neuroendocrine carcinoma was clinically identified with atypical symptoms.
In addition, there are some characteristics such as a higher incidence in men than in women, symptoms of dry cough, phlegm and close association with long-term smoking.
Pathology is considered the gold standard in diagnosing this malignancy with the following 5 criteria: Cells with characteristics of non-small cell carcinoma with neuroendocrine morphological structure (trabeculae, bands, palisades, pseudoroses); high mitotic rate (>10 NC/10HPF); high degree of necrosis; tumor components with cytological characteristics of other non-small cell carcinoma groups; IHC: Tumor cells are positive for neuroendocrine markers and histochemical markers of the corresponding non-small cell carcinoma components.
Cancer is a burden on people's health and the economy. According to the latest statistics from the International Agency for Research on Cancer (Globocan), each year Vietnam has an estimated 180,480 new cases and 120,184 deaths from cancer.
In 2022, Vietnam ranked 90th out of 185 countries in terms of new incidence rates, up 9 places compared to 2018. In terms of mortality rates, Vietnam ranked 50th out of 185. In particular, breast cancer, liver cancer, and lung cancer lead the way, with new incidence and mortality rates increasing each year.
Globocan said that each year in Vietnam, the number of deaths due to non-communicable diseases accounts for 77% of total deaths, of which cancer is the second leading cause.
In our country, colorectal cancer is one of the four most common cancers. The disease is on the rise, according to Globocan in 2022, the number of new cases is 16,800 and about 8,400 deaths per year.
In addition, according to data from Globocan in 2022, thyroid cancer ranked 6th with 6,122 new cases, while in 2020, thyroid cancer ranked 10th in the number of new cases in Vietnam. This data has shown a rapid increase in thyroid cancer.
According to Mr. Le Van Quang, Director of K Hospital, in 2023, the facility examined 446,830 patients, an increase of 34% compared to 2022.
Of which, the number of surgeries was more than 30,600 (up 22%); the number of chemotherapy sessions was nearly 36,000 (up 29%) and the number of radiotherapy sessions was nearly 15,900 (up 29%).
Common cancers in men include liver, lung, stomach, colorectal, and prostate cancers (accounting for about 65.8% of all cancers).
In women, common cancers include breast, lung, colorectal, stomach, and liver cancers (accounting for about 59.4% of all cancers). Common to both sexes, common cancers are liver, lung, breast, stomach, and colorectal cancers.
Source: https://baodautu.vn/ho-khan-co-the-canh-bao-ung-thu-d226822.html
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